Tired and heavy legs – pump up your circulation ready for action

INC | 4 June 2012

If you lead an active life, it stands to reason that your legs help get you where you need to go. To keep them in optimum condition you need to keep...

Read full article  Tired and heavy legs – pump up your circulation ready for action
If you lead an active life, it stands to reason that your legs help get you where you need to go. To keep them in optimum condition you need to keep their blood vessels strong and circulation healthy. An active or even a sedentary life can lead to heavy, swollen and tired legs.

Healthy blood circulation in your legs requires extra effort. Blood must be pumped from the legs against gravity to your heart. The blood vessels in your legs contain valves that keep keep blood going in only one direction. Standing or sitting for long periods of time can influence the quality of those blood valves and the condition of the arteries in your legs. This can lead to swollen, tired and tingling legs that can give you trouble getting up in the mornings.

By supplementing you diet with MASQUELIER’s® ANTHOGENOL® you have the opportunity to support tired, heavy legs by supporting blood vessels and valves. It keeps arteries supple, vessel walls strong and improves circulation so that tired and heavy legs stand a chance. Decades of scientific research has proven the positive health benefits of Masquelier's® ANTHOGENOL® for leg circulation by improving the elasticity and strength of blood vessels to keep legs healthy now and in the future.

MASQUELIER’s® TASTE FOR LIFE ESSENTIALS AWARD WINNER!

MASQUELIER's | 1 February 2013

MASQUELIER’s® French Pine Bark Extract announced the 2013 TASTE FOR LIFE ESSENTIALS AWARD WINNER!

In only the first year after it’s launch in...

Read full article  MASQUELIER’s® TASTE FOR LIFE ESSENTIALS AWARD WINNER!
MASQUELIER’s® French Pine Bark Extract announced the 2013 TASTE FOR LIFE ESSENTIALS AWARD WINNER!

In only the first year after it’s launch in the USA MASQUELIER’s® French Pine Bark Extract has already taken the prestigious 2013 TASTE FOR LIFE ESSENTIALS AWARD! One of only 8 products in the country to receive the Specialized Supplement Category award, for it’s standout success as an Essential Supplement. After over 60 years of success in Europe MASQUELIER’s® has now made it’s original French Pine Bark Extract with Original OPCs available to people in the USA. It's active ingredient has been prescribed in Europe for decades as a vascular protector that has been developed in conjunction with the discoverer of OPCs, the famous Professor Masquelier himself.

Professor Jack Masquelier – ground-breaking scientist in the field of nutrition and health – was the first to discover how to produce an extract from the bark of the French pine tree to release its potent health benefits. Professor Masquelier’s specific French Pine Bark extract is now available to the US market in its original form, combined with MASQUELIER’s® Original OPCs, the authentic antioxidant for vascular health.

MASQUELIER’s® Original OPCs found to delay aging of blood vessels

INC | 3 December 2008

New research shows a potential novel biological activity of oligomeric proanthocyanidins. As present in MASQUELIER’s® Original OPCs, this complex...

Read full article  MASQUELIER’s® Original OPCs found to delay aging of blood vessels
New research shows a potential novel biological activity of oligomeric proanthocyanidins. As present in MASQUELIER’s® Original OPCs, this complex phytonutrient was shown to delay aging in human vascular endothelial cells. The effect on what is technically called ‘senescence’ is possibly due to reducing DNA damage and oxidative stress.

The results of the research project, A Potential Role for Oligomeric Proanthocyanidins (OPCs) in delaying Senescence in Endothelial Cells, were presented by International Nutrition Company’s Dr. Geetha Achanta at the 15th Annual Meeting of the Society for Free Radical Biology and Medicine, held from 19 to 23 November in Indianapolis. The study was performed under supervision of Dr. Jan Andries Post at the Center for Cellular Architecture and Dynamics Department of the University of Utrecht in the Netherlands.

Compared to blood vessels in healthy people, blood vessels of people in the early stages of atherosclerosis or who are otherwise at risk for developing this disease, show a greater number of aged endothelial cells. This suggests that endothelial cell senescence might be associated with an increased risk for developing atherosclerosis. In the present research project it has been shown that MASQUELIER’s® Original OPCs may influence this risk factor.

Dr. Achanta, comments: “Atherosclerosis and the associated cardiovascular complications constitute the leading cause of death in the Western hemisphere. Smokers, hypertensives and the elderly are especially at risk. Aging of the vasculature has been associated with endothelial dysfunction, impaired angiogenesis and enhanced occurrence of atherosclerosis. The MASQUELIER’s® OPCs used in this study has been shown in our previous investigations to exhibit strong antioxidant activity. The findings from the current study suggest a novel biological activity for the product: delaying endothelial cell senescence. We are currently attempting to further elucidate the mechanisms by which the product delays endothelial cell senescence, which would provide a firm basis for testing its potential application in reducing risk of cardiovascular diseases.”

Arteries are lined on the inner side by a single, continuous layer of cells called endothelial cells. These endothelial cells have been found in laboratory experiments to undergo a finite number of cell divisions, after which growth halts. This phenomenon is called replicative cellular senescence and is suggested to occur in vivo with ageing of blood vessels. Senescence in endothelial cells also occurs upon exposure to oxidative stress, a phenomenon referred to as stress-induced premature senescence (SIPS). Interestingly, current research has shown that there is an increase in number of senescent cells in arteries of human subjects that are at risk of developing atherosclerosis, suggesting that delaying endothelial cell senescence might decrease the risk of developing atherosclerosis.

In the study, MASQUELIER’s® Original OPCs, a well characterized dietary supplement from Vitis vinifera seeds rich in specific oligomeric proanthocyanidins, was found to markedly delay the onset of replicative senescence in human endothelial cells cultured in the laboratory, using several established tests for assessing senescence. Additionally, the ingredient was also found to effectively delay SIPS caused by exposure to rotenone, a chemical substance that is known to generate oxidative stress.

Interestingly, the ability of MASQUELIER’s® OPCs to delay senescence was associated with a decrease in the levels of a marker of DNA damage and DNA terminal ends (gamma-H2AX), suggesting that the possible molecular mechanism by which OPCs delay senescence in endothelial cells is through reduction in DNA damage. This hypothesis is supported by observations made in other research studies, showing that extent of DNA damage and levels of gamma-H2AX increase as cells progress to senescence. Reducing levels of DNA damage could therefore delay cellular senescence.

In previous investigations performed at Utrecht University it has been shown to significantly protect human LDL from oxidation, further supporting a potential application for this product in reducing risk of atherosclerosis.

MASQUELIER’s® Original OPCs Effectively Protects human Low Density Lipoproteins

INC | 21 November 2007

Oligomeric proanthocyanidins, as present in the complex phyto-nutrient MASQUELIER’s® Original OPCs, directly protect human LDL from oxidation at...

Read full article  MASQUELIER’s® Original OPCs Effectively Protects human Low Density Lipoproteins
Oligomeric proanthocyanidins, as present in the complex phyto-nutrient MASQUELIER’s® Original OPCs, directly protect human LDL from oxidation at concentrations that reflect biologically-relevant or in vivo levels.

The results of the research project, Oligomeric proanthocyanidins effectively inhibit LDL oxidation: A Mechanistic study using a lipophilic, Oxidation-sensitive, Fluorescent Probe, were made public by Dr. Geetha Achanta at the 14th Annual Meeting of the Society for Free Radical Biology and Medicine, held last week in Washington DC. The research was performed in The Netherlands under supervision of Dr. Jan Andries Post at the Center for Cellular Architecture and Dynamics Department of the University of Utrecht.

Dr. Achanta commented: “The project aims at deepening our understanding of the ways OPCs protect the vascular wall, and potentially reduce risk of vascular disorders and cardiovascular complications. In research conducted last year, we found that OPCs are capable of protecting endothelial cells lining the blood vessels from oxidative damage and so reduce the risk on endothelial dysfunction and vascular disorders. This year’s research aims at studying the effects of OPCs on oxidation of LDL particles in plasma and their interaction with the vascular wall, a key factor that promotes inflammation in blood vessels resulting in atherosclerosis and cardiovascular complications. The results of the first phase of the project are extremely promising, because they indicate that OPCs, at levels found in circulation after oral intake, are capable of protecting LDL from oxidation, and appear to be more effective protectors than vitamin E.”

The results demonstrated that the likely mechanism by which MASQUELIER’s® Original OPCs protect LDL from oxidation is by effectively scavenging free radicals generated in both the water phase as well as the lipid phase which cause oxidation of the lipid (cholesterol)-rich LDL particles and triggers inflammation. This study used a highly sensitive, novel fluorescence method for detecting LDL oxidation.

The relevance of the data from this study is obvious. Atherosclerosis, the deterioration and functional impairment of the walls of our arteries, is a chronic inflammatory disease which constitutes the leading cause of morbidity, invalidity and bodily malfunction in the Western world. Vascular inflammatory disorders can also lead to angina pectoris, heart attacks and many other deadly, crippling, cumbersome or inconvenient health problems such as stroke, temporary ischemic attack (TIA), retinopathy (bad eyesight) and varicose veins. Moreover, vascular complications form the major side effect of diabetes. Increased risk for angina pectoris and an increased rate of sudden death have been observed in people previously diagnosed as diabetic. Today’s rapid increase in diabetes is due to the growing prevalence of obesity and overweight. The cascade of events that flow from obesity to diabetes to vascular inflammation show that the protection of the vascular wall must have absolute priority in the field of nutrition.

Free radicals play the determining role in the onset of vascular inflammatory processes. A major trigger for vascular inflammation is oxidation of plasma Low Density Lipoproteins (LDL). Oxidized - modified - LDL sets the inflammatory reaction in motion and the effects of this event result in many health- threatening conditions. The product-specific research, performed at the University of Utrecht (Netherlands), showed that, at concentrations that are biologically-relevant in humans, the flavanolic compound named MASQUELIER’s® Original OPCs significantly protected plasma LDL from oxidation by scavenging free radicals in the water phase and lipid phase, thereby interrupting LDL modification and inflammation.

Representing International Nutrition Company, the worldwide supplier of the MASQUELIER’s® compounds, Bert Schwitters said: “This places Dr. Masquelier’s product as an important nutritional factor that attenuates the onset of the inflammatory reactions that may lead to numerous cardiovascular complications. If we can protect cholesterol (LDL) from oxidation, we may be capable of reducing the body’s inflammatory response and increase the chances on a healthy future for the vascular system.”